After their car breaks down, two young American women in Germany wind up at a remote villa -- and soon find themselves trapped in a nightmare. Surgeon Dr. Josef Heiter (Dieter Laser) kidnaps them for his demented experiment to create a human "centipede." The plan includes removing their kneecaps so they must walk on all fours, then surgically connecting them and a Japanese man mouth-to-anus to form a human chain in this Dutch horror flick.