Coast to Coast AM is a late-night syndicated radio talk show which deals with a variety of topics, but usually ones that relate to the paranormal. It was created by Art Bell, airs seven nights a week 10:00 p.m. to 2:00 a.m. Pacific Time, and is distributed by Premiere Radio Networks. It is currently hosted by George Noory weekdays, Ian Punnett on Saturdays, George Knapp on Sundays and Art Bell as stand-in host.

Coast to Coast mostly emphasizes very unusual topics, and is full of personal stories related by callers. While program content varies, most nights are focused toward the paranormal, and subjects such as the occult, remote viewing, hauntings, shadow people, psychic predictions, conspiracy theories, UFOs, crop circles, cryptozoology and science fiction literature, among other paranormal topics. Since the terrorist attacks carried out in the United States on September 11, 2001, the events of that day (as well as conspiracy theories surrounding them) and current U.S. counter-terrorism strategy have also become frequent themes.

However, more conventional topics are sometimes discussed, with interviews with notable authors and political talk sometimes featured. After the theme song is played (Giorgio Moroder's The Chase from Midnight Express), the broadcast is typically kicked off with a reading of current events or news stories by the host, with callers weighing in if time permits. This is usually followed by a lengthy interview with the evening's guest, or hours of open phone lines.

Occasionally, roundtable discussions are held on one of the show's common topics. During hours of "open lines", calls are taken and put on air without any screening, at least according to original host Art Bell. More recently, under George Noory, open lines have added topics for callers to share their experiences or stories about a particular issue or situation.

The show has multiple call-in numbers, of which there are always at least five (as of 2005): for "east of the Rockies", "west of the Rockies", first-time callers, "international callers" and finally a "wild card" line. They are all announced at the beginning of each broadcast by Ross Mitchell. The shows opening, which is now famous, had been spoofed on the now defunct nationally-syndicated Phil Hendrie Show, with Hendrie imitating Mitchell's trademark deep voice and repeating his one phone number for all four lines.

On special occasions, Coast to Coast AM rolls out more numbers, including lines that are reserved for special "themed" callers, for example those who claim to be from other dimensions, time periods, and those possessed by spirits. The Halloween edition of Coast to Coast becomes Ghost to Ghost, as listeners call in with their ghost stories. The New Year's Eve show usually entails listeners calling in their predictions for the coming year, and the host (commonly Art Bell) rating the predictions made a year earlier.

In recent years, the host of the New Year's Eve prediction show preface open line predictions that callers may not predict the assination or death of the president. Apparently such predictions made in the past have resulted in visits from the Secret Service to the host's home.

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