Hedwig and the Angry Inch is a 2001 musical film based on the stage musical of the same title about a fictional rock band fronted by an East German transgender singer. The film was adapted and directed by John Cameron Mitchell, who also portrayed the title role. The music and lyrics are by Stephen Trask.

The musical, and anything Hedwig related, has gathered a devoted cult following. For the soundtrack, Hedwig's songs were recorded by John Cameron Mitchell (lead vocals), Stephen Trask, Miriam Shor, Bob Mould (of Hüsker Dü), Ted Liscinski, Perry L. James, Alexis Fleisig, and Eli Janney.

Tommy Gnosis' songs were recorded by Stephen Trask (lead vocals), Miriam Shor, Bob Mould, Ted Liscinski, Perry L. James, Scott McCloud, Eli Janney, Alexis Fleisig, and Johnny Temple. In 2003, a CD of the film's song covers by such artists as Yoko Ono and Cyndi Lauper was released.

It benefited the Hetrick-Martin Institute and was named after one of the musical's most popular songs "Wig in a Box".

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