Drusilla, nicknamed "Dru", is a fictional character created by Joss Whedon and David Greenwalt for the cult television series, Buffy the Vampire Slayer and Angel. The character is portrayed by Juliet Landau. Drusilla's history unfolds in flashbacks scattered among numerous episodes of both Buffy the Vampire Slayer and Angel; they are not presented in chronological order.

In "Lie to Me", Angel explains that, in 1860 when he was still Angelus, he became obsessed with Drusilla, a beautiful young Catholic woman who lived with her parents and two sisters in London, England. Drusilla had psychic abilities, and was capable of occasionally foretelling the future, especially tragic situations. However, she believed this to be an evil affliction and wished to enter a nunnery to cleanse herself.

Angelus sensed her purity and became obsessed with destroying her, as Drusilla had the potential for sainthood. Angelus tortured and killed Drusilla's entire family, causing her to flee to a convent in Prague. On the day she was to take her holy vows, Angelus made her watch as he killed every person in the convent and engaged in sexual relations with Darla.

The trauma of Angelus's atrocities drove Drusilla insane, and Angelus chose to turn her into a vampire, as he considered her a masterpiece, a testament to his talent. After being sired, Drusilla, now a predator but with only a childlike sexuality, joined Angelus and Darla on their murderous travels. In 1880, Drusilla sired the young poet William, who joined the group.

She and William, later known as "Spike", shared an intimate relationship, though Angelus continued to engage in sexual relations with Dru as well.

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