The Lizard (Dr. Curt Connors) is a fictional character, a supervillain in the Marvel Comics universe and enemy of Spider-Man. The Lizard first appeared in The Amazing Spider-Man #6 (November 1963), and was created by Stan Lee and Steve Ditko.

In 2009, the Lizard was named IGN's 62nd Greatest Villain of All Time. Curtis Connors was born in Coral Gables, Florida. He was a gifted surgeon who enlisted in the army and was sent off to war.

He performed emergency battlefield surgery on wounded GIs, but his right arm was injured in a blast and had to be amputated. After his return to civilian life as a research technologist, he became obsessed with uncovering the secrets of reptilian limb regeneration and studied reptilian biology extensively. From his home in the Florida Everglades, he finally developed an experimental serum taken from reptilian DNA.

He successfully regrew the missing limb of a rabbit and then, despite the warnings of his wife Martha, chose to test it on himself. Connors ingested the formula and his missing arm did indeed grow back. The formula had a side effect; Connors was subsequently transformed into a reptilian humanoid monster.

Spider-Man discovered this situation during a trip to Florida to investigate newspaper reports of the Lizard. Spidey was then able to use Connors' notes to create an antidote to restore him to his human form and mentality. Later, Curt Connors relocated to New York City.

He was able to repay Spider-Man by developing a formula to save May Parker's life after Peter Parker had given his aunt his radioactive blood during a transfusion, unintentionally putting her in mortal peril. It later became clear that the success of Connors' apparent cure from the Lizard persona was short-lived. A repeating pattern occurred, with stress or a chemical reaction turning Connors into the Lizard, Spider-Man fighting him, and then forming some kind of temporary cure to reverse the transformation until the next time.

A second personality had formed with the Lizard, one with the familiar goal shared by many villains of taking over the world. The Lizard envisioned a world where all humans had been transformed into (or replaced by) super-reptiles like himself. Despite the Lizard's overall hatred of humans, he was often shown to be unwilling to harm his wife Martha or young son Billy.

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