A Prairie Home Companion is a live radio variety show created and hosted by Garrison Keillor. The show runs two hours on Saturdays from 5 to 7 p.m. Central Time, and usually originates from the Fitzgerald Theater in St. Paul, Minnesota, although it is frequently taken on the road.

A Prairie Home Companion is known for its musical guests, especially folk and traditional musicians, tongue-in-cheek radio drama, and Keillor's comedic storytelling segment, "News from Lake Wobegon." The radio program inspired a 2006 film of the same name, directed by Robert Altman and featuring Keillor, Lily Tomlin, Meryl Streep, Lindsay Lohan, Tommy Lee Jones and Kevin Kline. It is produced by Prairie Home Productions and distributed by American Public Media, and is most often heard on public radio stations in the United States. The show has a long history, existing in a similar form as far back as 1974, and borrowing the name from a radio program in existence in 1969.

The program was named after the Prairie Home Cemetery in Moorhead, Minnesota, located next to Concordia College.

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