The Baxter Building is a fictitious 35-story office building in Manhattan whose five upper floors house the Fantastic Four's headquarters in the Marvel Universe. The Baxter Building first appeared in Fantastic Four #3 (March 1962) and was created by Stan Lee and Jack Kirby. Located at 42nd Street and Madison Avenue in New York City, it had been built in 1949 by the Leland Baxter Paper Company.

Originally designed as a high-rise industrial site to accommodate pulp recycling machinery to serve the mid-Manhattan area, each floor height is 24 feet (7.3 m). The building's steel frame construction utilized the first application of "K bracing" in the world and is one of the strongest structures of its kind. The Baxter Building is located a few city blocks from the United Nations Building.

Reed Richards has applied for many land-use zone variations to allow massive reconstruction of the top five floors for the installation of a heavily-silenced silo, with a muffled rocket.

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