Drugs can be used in many different ways, as detailed below. People can use drugs to relieve pain or discomfort or to cure or prevent disease. Recreational drug use is the use of psychoactive drugs for recreational purposes rather than for work, medical or spiritual purposes, although the distinction is not always clear.

At least one psychopharmacologist who has studied this field refers to it as the 'Fourth Drive,' arguing that the human instinct to seek mind-altering substances has so much force and persistence that it functions like the human drives for hunger, thirst and shelter. The concept of responsible drug use is that a person can use recreational drugs with reduced or eliminated risk of negatively affecting other parts of one's life or other people's lives. Advocates of this idea point to the many well-known artists and intellectuals who have used drugs, experimentally or otherwise, with few detrimental effects on their lives.

Critics argue that the drugs are escapist--and dangerous, unpredictable and sometimes addictive; thus predicating the idea of a responsible use of drugs as an idea, ultimately disputable upon debate.

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