Egon Spengler, Ph.D is a fictional character appearing in the films Ghostbusters and Ghostbusters II, and in the animated television series The Real Ghostbusters and later Extreme Ghostbusters. He is a member of the Ghostbusters, and one of the three doctors of parapsychology on the team. Spengler is portrayed by Harold Ramis in the films, and voiced by Maurice LaMarche in the cartoon series.

The character of Egon Spengler was named after Oswald Spengler and a classmate of Harold Ramis' at Senn High School named Egon Donsbach who was a Hungarian refugee. Maurice LaMarche stated that when he auditioned for the part of Egon Spengler in The Real Ghostbusters, he was asked not to do an impression of Harold Ramis, a request he ignored because impressions were one of his strengths as a performer and there was no other way he could imagine properly portraying the character other than to follow Ramis's example, and got the part anyway. LaMarche said in an interview that he did two different takes, one where he impersonated Ramis, the other where he tried a more "Woody Allen" like approach, which he admitted didn't suit the character's physicality as depicted in animation.

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