Glenn Quagmire is a character on the animated series Family Guy, best known for his hypersexuality. Creator and voice actor Seth MacFarlane describes Quagmire as "An appalling human being who is still caught in the rat-pack era" based on anachronistic 1950s party animal clichés. His neighbor and friend Peter Griffin describes him as a "heartless sex hound." His often inappropriate brand of humour has been referred to as "PG-37".

Many of the storylines, and most of the jokes, about Quagmire feature his wanton and deviant sexual behavior. He is known for extreme predatory behavior, such as drugging the drinks of his dates. Quagmire is a registered sex offender, possesses a foot fetish, and is not above sex with a dead woman.

While out at sea with Peter and his friends, he confesses to a seemingly endless chain of bizarre sexual acts, such as picking up illegal aliens at Home Depot and Jo-Ann Fabrics stores to suffocate him while he masturbated, and giving a reach around to a spider monkey while reciting the Pledge of Allegiance.

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