The human skeleton consists of both fused and individual bones supported and supplemented by ligaments, tendons, muscles and cartilage. It serves as a scaffold which supports organs, anchors muscles, and protects organs such as the brain, lungs and heart. The biggest bone in the body is the femur and the smallest is the stapes bone in the middle ear.

In an adult, the skeleton comprises around 13% of the total body weight, and half of this weight is water. Fused bones include those of the pelvis and the cranium. Not all bones are interconnected directly: There are three bones in each middle ear called the ossicles that articulate only with each other.

The hyoid bone, which is located in the neck and serves as the point of attachment for the tongue, does not articulate with any other bones in the body, being supported by muscles and ligaments. Early in gestation, a fetus has a cartilaginous skeleton from which the long bones and most other bones gradually form throughout the remaining gestation period and for years after birth in a process called endochondral ossification. The flat bones of the skull and the clavicles are formed from connective tissue in a process known as intramembranous ossification, and ossification of the mandible occurs in the fibrous membrane covering the outer surfaces of Meckel's cartilages.

At birth a newborn baby has approximately 231 bones , whereas on average an adult human has 206 bones (these numbers can vary slightly from individual to individual). The difference comes from a number of small bones that fuse together during growth, such as the sacrum and coccyx of the vertebral column. The sacrum (the bone at the base of the spine) consists of five bones which are separate at birth but fuse together into a solid structure in later years.

An infant is born with bones of cartilage, called epiphyseal plates, between segments of bone to allow further growth. Longitudinal bone growth ends when the bone of the epiphysis and diaphysis fuses. This process, called epiphyseal plate closure, happens at about 18 years of age in females and 21 years of age in males.

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