Phi Mu Alpha Sinfonia (also known as Phi Mu Alpha, or simply Sinfonia, or in an archaic usage as the Sinfonia) is an American collegiate social fraternity for men who wish to devote themselves to the advancement of music in America and who wish to associate with others who share that interest. More than 150,000 men have been initiated into Phi Mu Alpha Sinfonia since its founding in 1898, and the fraternity currently has over 5,000 active collegiate members in 226 collegiate chapters throughout the United States. Phi Mu Alpha Sinfonia operates independently from any of the major governing councils for collegiate fraternities in the United States such as the North-American Interfraternity Conference, though it is a member of other interfraternal organizations such as the Association of Fraternity Advisors, the Fraternity Communications Association, and the National Interfraternity Music Council.

Since 1970, Phi Mu Alpha Sinfonia has been headquartered at Lyrecrest, an estate on the northern outskirts of Evansville, Indiana. Phi Mu Alpha Sinfonia was founded as the Sinfonia Club at the New England Conservatory of Music in Boston, Massachusetts. Ossian Everett Mills, bursar of the conservatory, had been holding devotional meetings with a small group of male students since 1885.

Mills was profoundly interested in the physical, mental, moral, and spiritual development of the conservatory's students. Mills sought to encourage the personal development of the young men at the conservatory through wholesome social interaction among them. This led Mills to suggested that the "Old Boys" of the conservatory invite the "New Boys" to a "get acquainted" reception on September 22, 1898.

Several of the men who attended the reception began to discuss the possibility of organizing a more permanent social club, and a meeting was planned for October 6, 1898, for that purpose. The minutes of the first meeting of the Sinfonia Club on October 6, 1898, record the following:

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