PLoS ONE is an open access, "online only", scientific journal from the Public Library of Science. It covers primary research from any discipline within science and medicine. All submissions go through a rigorous, internal and external pre-publication peer review but are not excluded on the basis of lack of perceived importance or adherence to a scientific field.

The PLoS ONE online platform has post-publication user discussion and rating features. PLoS ONE articles are indexed in PubMed, MEDLINE, PubMed Central, Scopus, Google Scholar, the Chemical Abstracts Service (CAS), RefAware, EMBASE, AGRICOLA, BIOSIS Previews, and The Zoological Record. PLoS ONE was launched in December 2006 as a beta version.

It launched with Commenting and Note making functionality, and added the ability to rate articles in July 2007. In September 2007 the ability to leave "trackbacks"[clarification needed] on articles was added. In August 2008 it moved from a weekly publication schedule to a daily one, publishing articles as soon as they became ready.

In October 2008 PLoS ONE came out of "beta". Also in September 2009, as part of its "Article-Level Metrics" program, PLoS ONE made the full online usage data for every published article (HTML page views, PDF, and XML downloads) publicly available. In 2006 the journal published 138 articles; in 2007 it published just over 1,200 articles; and in 2008 it published almost 2,800 articles, making it the largest open access journal in the world.

As of September 2009, there were over 7,200 articles available and it is projected to become the third largest journal in the world (by volume) with an estimated 2009 annual output of 4,600 articles.

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