Samantha "Sam" McCall is a fictional character on the ABC soap opera, General Hospital portrayed by Kelly Monaco since October 2003 and has since renewed her contract. The role of Sam has been portrayed by Playboy's April 1997 Playmate of the Month and the first champion on ABC's Dancing with the Stars, Kelly Monaco, since October 1, 2003. In 2006, Monaco was nominated for a Daytime Emmy in the category of Outstanding Lead Actress in a Drama Series for her role.

Sam is the biological daughter of Alexis Davis who had Sam as a teen and was forced to give her up by Sam's grandfather, Mikkos Cassadine. Sam was adopted by Cody McCall and Evelyn Bass. Cody and Evelyn's older son, Danny McCall, was mentally handicapped.

Evelyn decided that she didn't want Sam, so she took her son Danny and left. Sam was raised by Cody, who taught her how to salvage and run cons. When Sam found out about her mother and brother, she went to find them.

In an accident, Danny burned his mother's house down with her inside. Sam continued to run cons as her father taught her while using the money to take care of Danny. She married several wealthy men in order to scam them out of their money, and provide a life for herself and her brother.

In August 2009, fans were shocked by a casting call for the character. Despite rumors and speculation, Monaco's co-stars Steve Burton (Jason Morgan) and Nancy Lee Grahn (Alexis Davis) have denied that she is departing from the show. If Kelly Monaco were to leave the fan favorite role behind, it would leave a major hole in the canvas and the ratings would likely plummet as many fans are pleased with the "JaSam" reunion.

The casting call that was put out also describes another character, Claudia Corinthos, whose portrayer is leaving the series. Sam arrived in Port Charles on October 1, 2003, and quickly teamed up with Jasper "Jax" Jacks to look for the 5 lucky cards of the Dead Man's hand that would save Jax's father's life. When Jax's father dies, however, there is friction because Sam had also pursued the cards for herself.

Jax and Sam consummate their relationship, but they break up when Jax discovers Sam's role in tampering his car. Sam begins a sexual relationship with Sonny Corinthos, from which she soon gets pregnant and makes an enemy of Sonny's wife, Carly Jacks. Jason Morgan (Sonny's right hand man) asks her if he could pose as the baby's father so that Sonny and Carly could stay together, but Sonny soon learns that Sam is carrying his child.

It was around this time that Sam began a friendship with Jason and the two almost get married, but Sam declares that she doesn't love him at the time and she doesn't want to make a false commitment. During the Port Charles Hotel fire, Sam sleeps with Jax, causing friction between her and Sonny, so she goes to live with Jason since he was posing as her baby's father. Jason and Carly also protect Sam from her abusive ex-boyfriend Nico.

When Sonny's newly-discovered daughter, Kristina Corinthos, is in need of stem cells from Sam's unborn child, Sam initially refuses but goes into labor after a confrontation with Alexis, causing her baby to be stillborn. Jason and Sam had decided to name her daughter Lila Morgan after Jason's late grandmother Lila Morgan Quartermaine, but because it was never made official, the child was buried as Baby Girl McCall in November 2004. Sam and Jason admitted their love for one another.

In January 2005, they become engaged, and also become foster parents of sorts when Sam agrees to care for the child of a young mother named Bridget. Jason names the baby Hope, but Bridget decides that she wants her baby back. To avoid a court battle, Jason decides Hope should be returned to her mother.

Sam is hurt and angry at this decision, but she is there for Jason when he loses his memory in 2005. Sam convinces Jason to undergo a controversial treatment administered by his old girlfriend, Dr. Robin Scorpio.

After Jason loses his memory, he and Sam fall in love all over again and he proposes to her a second time before he begins his treatment. The treatment is a success and causes him to regain his memory.

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