Dr. Sara Tancredi is a fictional character from the American television series, Prison Break. She is played by Sarah Wayne Callies.

Her role in the first season of the series is a prison doctor. Raised in Chicago, Sara Tancredi's ambitions to be a doctor began when she was very young. While at Northwestern University, where she was a Phi Beta Kappa, she was introduced to the works of Mahatma Gandhi and decided to become a humanitarian, which later influenced her decision to work at Fox River State Penitentiary.

Another factor which contributed to her occupational choice was her past morphine addiction, culminating in being unable to help a boy after he was run over because she was high, which was revealed in a flashback episode of the first season, "Brother's Keeper". At 29 years old, Dr. Sara Tancredi was one of the few doctors working at Fox River.

Her chosen occupation became a constant source of stress for her father. Sara is the only child of the Governor of Illinois, Frank Tancredi (John Heard). Due to her father's hectic political career and vastly differing beliefs, she did not have a close relationship with him.

In episode "Buried", it was revealed that her mother has already died. In the first season, Sara is mostly featured in scenes with Michael Scofield, while in the second season, Sara has mainly appeared in scenes with Frank Tancredi, Paul Kellerman or by herself. Thus far, she has appeared in every episode of seasons 1, 2 and 4 except for second season episodes, "Otis" and "John Doe".

After the death of Robin Tunney's character, Veronica Donovan, Sara Tancredi became the only remaining principal female character. Coincidentally, just like Veronica (who was killed off in the first episode of the second season "Manhunt"), she was "killed off" early in the third season, apparently beheaded by Gretchen Morgan, and her "head" was delivered in a box to Lincoln Burrows. In season 4 it is discovered that the head was a ploy and that Sara is alive.

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