University Circle is the cultural, educational, and medical center of Greater Cleveland, and is located on the east side of Cleveland, Ohio. University Circle occupies approximately 550 acres (2.2 km²) around the campus of Case Western Reserve University and the adjacent Wade Park Oval. It borders Cleveland's Little Italy, home to many private art galleries and restaurants, as well as the neighborhoods of Hough, Glenville, Buckeye-Shaker, and Fairfax (also known as Midtown).

University Circle is a major source of employment in the Cleveland area, currently providing more than 30,000 jobs in a variety of fields. Over 13,000 undergraduate, graduate, and professional students attend area institutions, and approximately 2.5 million people visit the Circle each year. University Circle Incorporated, a not-for-profit corporation established in 1957, fulfills many administrative and quasi-governmental functions for the area, including security, transportation administration, and marketing.

Nearly 50 cultural, medical, educational, religious, and social service institutions are based in the University Circle area, the largest of which is Case Western Reserve University. University Circle houses a large number of allied and independent institutions, most of which are members of University Circle Incorporated. The Cleveland Museum of Art, a world-renowned art museum situated in front of Wade Lagoon, is currently undertaking a massive expansion project that will more than double its exhibit space.

The Cleveland Museum of Natural History is located in the Circle as well. Severance Hall is home to the Cleveland Orchestra, one of the United States' Big Five orchestras. The Cleveland Botanical Garden includes a greenhouse offering two ecosystems: Madagascar desert and Costa Rica cloud forest.

The Cleveland Institute of Art, Cleveland Cinematheque, and Sculpture Center are located in the Circle. Case Medical Center is one of the nation's premier cancer hospitals and is closely affiliated with Case Western Reserve University. The Louis Stokes Veteran's Administration Medical Center is another medical institution in the area.

The Ohio College of Podiatric Medicine is currently located in the Circle, but will soon move to suburban Independence. The Cleveland Institute of Music and the Cleveland Music School Settlement are also located here. The Circle is home to a variety of smaller museums as well, such as The Western Reserve Historical Society and Crawford Auto-Aviation Museum, the Children's Museum of Cleveland and the Dittrick Museum of Medical History.

Located nearby are a number of other museums, places of worship, and specialty health care facilities, including the Cleveland Clinic and the Cleveland Play House.

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