The Upstate is the region in northwestern South Carolina, United States, also known as The Upcountry, which is the historical term. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. The region's population was 1,220,542 at the 2000 Census.

A July 1, 2007 United States Census Bureau estimate placed the population at 1,335,571..The Upstate is the fastest growing region in the state, and given its strategic position between Atlanta and Charlotte, future development and growth prospects are bright. After BMW's initial investment, foreign companies especially from Germany have made a substantial presence in the Upstate, and several large corporations have established regional, national, or continental headquarters in the region.

Greenville is the largest city in the region and the base of most commercial activity. Spartanburg is the second largest city in the region. The third largest city in the region is Anderson.

There are ten counties included in the upstate of South Carolina: Greenville, Spartanburg, Anderson, Pickens, Cherokee, Oconee, Union, Laurens, Greenwood, and Abbeville. There is a total of three Metropolitan Statistical Areas and four Micropolitan Statistical Areas. The larger Greenville–Spartanburg–Anderson Combined Statistical Area includes all three metropolitan areas and three out of the four micropolitan areas (excluding Greenwood).

One county, Abbeville, is not part of any metropolitan or micropolitan area. As of the 2000 Census, the Greenville-Spartanburg-Anderson CSA had a population of 1,128,104 (though a July 1, 2007 estimate placed the population at 1,221,881).

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